Article

Toxic PR poly-dipeptides encoded by the <i>C9orf72</i> repeat expansion target Kapβ2 and dysregulate phase separation of low-complexity domains

2019-10-21

Abstract excerpt

<h4>ABSTRACT</h4> Low-complexity (LC) domains of proteins are found in about one fifth of human proteome, and a group of LC-domains form labile cross-β polymers and liquid-like droplets. Polymers and droplets formed from LC-domains are dynamically regulated by posttranslational modifications and molecular chaperones including nuclear transport receptors. Repeat expansion in the first intron of a gene designated...

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Literature Corpus work: 5bc11d20-36ed-5c7c-b3a6-f34194720a67
DOI: 10.1101/812099

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