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Stress granule mediated protein aggregation and underlying gene defects in the FTD-ALS spectrum

15 Oct 2019

Abstract excerpt

Stress granules (SGs) are dynamic membraneless compartments composed out of RNA-binding proteins (RBPs) and RNA molecules that assemble temporarily to allow the cell to cope with cellular stress by stalling mRNA translation and moving synthesis towards cytoprotective proteins. Aberrant SGs have become prime suspects in the nucleation of toxic protein aggregation in frontotemporal dementia (FTD) and amyotrophic...

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PMID: 31626953
DOI: 10.1016/j.nbd.2019.104639

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