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Article

Altered Phase Separation and Cellular Impact in C9orf72-Linked ALS/FTD

21 Apr 2021

Abstract excerpt

Since the discovery of the C9orf72 repeat expansion mutation as causative for chromosome 9-linked amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in 2011, a multitude of cellular pathways have been implicated. However, evidence has also been accumulating for a key mechanism of cellular compartmentalization—phase separation. Liquid-liquid phase separation (LLPS) is fundamental for the...

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PMID: 33967699
DOI: 10.3389/fncel.2021.664151

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