Article

Allosteric modulation of TIA-1 phase separation by double serine phosphorylation

2025-08-25

Abstract excerpt

In response to diverse harmful stimuli, eukaryotic cells generate cytoplasmic stress granules (SGs), mainly composed of mRNAs and RNA-binding proteins (RBPs). RBPs are fine-tuned by a diverse array of post-translational modifications (PTMs), with important consequences for the assembly, dynamics and clearance of SGs. One of the best characterized SG nucleators is the RBP T-cell intracellular antigen 1 (TIA-1), alt...

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Literature Corpus work: 59c1cf98-36af-57a5-a596-2da681fdb74c
DOI: 10.1101/2025.08.21.671602

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