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Article

Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation.

Molecular cell - 1 Feb 2018

Ryan Veronica H, Dignon Gregory L, Zerze Gül H, Chabata Charlene V, Silva Rute, Conicella Alexander E, Amaya Joshua, Burke Kathleen A, Mittal Jeetain, Fawzi Nicolas L

Abstract excerpt

hnRNPA2, a component of RNA-processing membraneless organelles, forms inclusions when mutated in a syndrome characterized by the degeneration of neurons (bearing features of amyotrophic lateral sclerosis [ALS] and frontotemporal dementia), muscle, and bone. Here we provide a unified structural view of hnRNPA2 self-assembly, aggregation, and interaction and the distinct effects of small chemical changes-disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29358076
DOI: 10.1016/j.molcel.2017.12.022
PMCID: PMC5801700

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