Article

Disease-linked mutations in hnRNPA2B1 accelerate condensate maturation and promote amyloid aggregation

2026-08-28

Abstract excerpt

Heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) is a multifunctional RNA-binding protein that undergoes liquid-liquid phase separation (LLPS), contributing to the assembly of membraneless organelles across different cellular contexts. However, dysregulated phase separation can drive the transition from functional condensates to pathological protein aggregates. Two mutations in the low-complexity domain (L...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: ffb20d02-3932-503f-a0ac-67c54cfc49de
DOI: 10.64898/2026.08.28.747731

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Disease-linked mutations in hnRNPA2B1 accelerate condensate maturation and promote amyloid aggregationDOI 10.64898/2026.08.28.747731Read

Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation.Semantic proximity Read

Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation.Semantic proximity Read

Distinct roles of hnRNPH1 low-complexity domains in splicing and transcriptionSemantic proximity Read

DEFINING THE DIVERSITY OF HNRNPA1 MUTATIONS IN CLINICAL PHENOTYPE AND PATHOMECHANISMSemantic proximity Read

hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation.Semantic proximity Read

Aberrant phase separation and cancer.Semantic proximity Read

Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.Semantic proximity Read

Pathological phase transitions in ALS-FTD impair dynamic RNA-protein granules.Semantic proximity Read

Phase separation behavior of TDP-43 governs its protein interactome and regulation of alternative splicingSemantic proximity Read

Advances in Nucleotide Repeat Expansion Diseases: Transcription Gets in Phase.Semantic proximity Read

The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structureSemantic proximity Read

Disrupting pathologic phase transitions in neurodegenerationSemantic proximity Read