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Stress Granule Homeostasis, Aberrant Phase Transition, and Amyotrophic Lateral Sclerosis.

ACS chemical neuroscience - 17 Aug 2022

Li Zhanxu, Liu Xionghao, Liu Mujun

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. In recent years, a large number of ALS-related mutations have been discovered to have a strong link to stress granules (SGs). SGs are cytoplasmic ribonucleoprotein condensates mediated by liquid-liquid phase separation (LLPS) of biomacromolecules. They help cells cope with stress. The normal physiological functions of SGs are dependent on...

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PMID: 35905138
DOI: 10.1021/acschemneuro.2c00262

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