Article

Phase separation of toxic dipeptide repeat proteins related to C9orf72 ALS/FTD

2020-02-01

Abstract excerpt

The expansion mutation in the C9orf72 gene is the most common known genetic cause for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This mutation can produce five dipeptide repeat proteins (DPRs), of which three are known to be toxic: poly-PR, poly-GR, and poly-GA. The toxicity of poly-GA is attributed to its aggregation in the cytoplasm, while for poly-PR and poly-GR several toxicity path...

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Literature Corpus work: 4b1d076a-ec52-5a16-ac90-9cd62d975719
DOI: 10.1101/2020.01.31.926428

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