Article

Fully accessible fitness landscape of oncogene-negative lung adenocarcinoma

2023-02-01

Abstract excerpt

<h4>ABSTRACT</h4> Cancer genomes are almost invariably complex with genomic alterations cooperating during each step of carcinogenesis. In cancers that lack a single dominant oncogene mutation, cooperation between the inactivation of multiple tumor suppressor genes can drive tumor initiation and growth. Here, we shed light on how the sequential acquisition of genomic alterations generates oncogene-negative lung t...

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Literature Corpus work: bfde2cf8-b59c-5b7b-9303-5016f61d36e1
DOI: 10.1101/2023.01.30.526178

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