Article

Context-dependent selection sculpts mutational landscapes in the normal lung

2026-07-02

Abstract excerpt

<title>Abstract</title> <p>Just as organismal evolution is driven by environmental changes, somatic evolution is similarly driven by changes in tissue environments, whether caused by the normal process of aging, by lifestyle choices, or by extrinsic exposures. We present deep mutational profiling using duplex sequencing of over 370 samples of non-malignant lung tissue from 202 subjects, showing how aging, smoking...

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Literature Corpus work: 2147d377-34d5-5f91-ba72-085d1a2ffbcb
DOI: 10.21203/rs.3.rs-10195584/v1

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