Genetic background sets the trajectory of experimental cancer evolution.

doi:10.1038/s41586-026-10821-z

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic background sets the trajectory of experimental cancer evolution.

Nature - 1 Sept 2026

Aitken Sarah J, Connor Frances, Feig Christine, Rayner Tim F, Lukk Margus, Luft Juliet, Aitken Stuart, Arnedo-Pac Claudia, Hayes James F, Nicholson Michael D, Ewing Ailith, Sundaram Vasavi, Verburg Jan C, Connelly John, Anderson Craig J, Behm Mikaela, Campbell Susan, Daunesse Maëlle, Kaiser Vera B, Kentepozidou Elissavet, Pich Oriol, Redmond Aisling M, Santoyo-Lopez Javier, Sentís Inés, Talmane Lana, Flicek Paul, López-Bigas Núria, Semple Colin A, Taylor Martin S, Odom Duncan T

Abstract excerpt

Human cancers are heterogeneous1. Dissecting how germline genetic variation and environmental factors shape tumour evolution using human datasets is limited by inherent diversity in genetic backgrounds2 and environmental exposures3-5. Here, to overcome these limitations, we re-ran early tumour evolution hundreds of times in diverged inbred mouse strains, generating matched histology and whole-genome and...

Read the complete abstract on PubMed

Topics

Animals
Female
Humans
Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Genetic Background

Evolution, Molecular

Neoplasms

Mutation

Selection, Genetic

Disease Progression

Epistasis, Genetic

Genetic Predisposition to Disease

Genetic Variation

Source

Open in PubMed Open full text

Identifiers

PMID: 42486977
DOI: 10.1038/s41586-026-10821-z
PMCID: PMC13600922

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic background sets the trajectory of experimental cancer evolution.PMID 42486977Read ↗

Genetic background sets the trajectory of cancer evolutionSemantic proximity Read ↗

Background genetics and new mutations interact to direct cancer evolutionSemantic proximity Read ↗

Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression.Semantic proximity Read ↗

Mouse models in the era of large human tumour sequencing studies.Semantic proximity Read ↗

Capturing cancer evolution using genetically engineered mouse models (GEMMs)Semantic proximity Read ↗

Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers.Semantic proximity Read ↗

Building a healthy mouse model ecosystem to interrogate cancer biology.Semantic proximity Read ↗

Tumour promotion through the lens of evolution.Semantic proximity Read ↗

Oncogenic context shapes the fitness landscape of tumor suppressionSemantic proximity Read ↗

Tobacco smoke alters the trajectory of lung adenocarcinoma evolution via effects on somatic selection and epistasisSemantic proximity Read ↗

A disease model resource reveals core principles of tissue-specific cancer evolution.Semantic proximity Read ↗

A Lung Cancer Mouse Model DatabaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.