Article

Tumor suppressor genotype influences the extent and mode of immunosurveillance in lung cancer

2025-01-19

Abstract excerpt

The impact of cancer driving mutations in regulating immunosurveillance throughout tumor development remains poorly understood. To better understand the contribution of tumor genotype to immunosurveillance, we generated and validated lentiviral vectors that create an epi-allelic series of increasingly immunogenic neoantigens. This vector system is compatible with autochthonous Cre-regulated cancer models, CRISPR/C...

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Literature Corpus work: 95cd31d3-1631-5ed5-8c48-ea2203a16c93
DOI: 10.1101/2025.01.15.633175

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