Article
Causal associations between risk factors and common diseases inferred from GWAS summary data.
Nature communications - 15 Jan 2018
Zhu Zhihong, Zheng Zhili, Zhang Futao, Wu Yang, Trzaskowski Maciej, Maier Robert, Robinson Matthew R, McGrath John J, Visscher Peter M, Wray Naomi R, Yang Jian
Abstract excerpt
Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the risk factors are cause or consequence of disease, or whether the associations are the result of confounding. We develop and apply a method (called GSMR) that performs a multi-SNP Mendelian randomization analysis using summary-level data from genome-wide association...
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