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Article

Welch-weighted Egger regression reduces false positives due to correlated pleiotropy in Mendelian randomization.

American journal of human genetics - 2 Dec 2021

Brown Brielin C, Knowles David A

Abstract excerpt

Modern population-scale biobanks contain simultaneous measurements of many phenotypes, providing unprecedented opportunity to study the relationship between biomarkers and disease. However, inferring causal effects from observational data is notoriously challenging. Mendelian randomization (MR) has recently received increased attention as a class of methods for estimating causal effects using genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34861175
DOI: 10.1016/j.ajhg.2021.10.006
PMCID: PMC8715134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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