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Article

Inferring causal direction between two traits in the presence of horizontal pleiotropy with GWAS summary data.

PLoS genetics - 1 Nov 2020

Xue Haoran, Pan Wei

Abstract excerpt

Orienting the causal relationship between pairs of traits is a fundamental task in scientific research with significant implications in practice, such as in prioritizing molecular targets and modifiable risk factors for developing therapeutic and interventional strategies for complex diseases. A recent method, called Steiger's method, using a single SNP as an instrument variable (IV) in the framework of Mendelian...

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PMID: 33137120
DOI: 10.1371/journal.pgen.1009105
PMCID: PMC7660933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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