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Article

Robust inference of bi-directional causal relationships in presence of correlated pleiotropy with GWAS summary data.

PLoS genetics - 1 May 2022

Xue Haoran, Pan Wei

Abstract excerpt

To infer a causal relationship between two traits, several correlation-based causal direction (CD) methods have been proposed with the use of SNPs as instrumental variables (IVs) based on GWAS summary data for the two traits; however, none of the existing CD methods can deal with SNPs with correlated pleiotropy. Alternatively, reciprocal Mendelian randomization (MR) can be applied, which however may perform...

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Share to Causality
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 35576237
DOI: 10.1371/journal.pgen.1010205
PMCID: PMC9135345

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