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Spatial multi-omics reveals targetable immunosuppressive macrophage T-cell interactions in human AML bone marrow

2026-08-07

Abstract excerpt

<h4>Summary</h4> The immunosuppressive bone marrow microenvironment is an important contributor to the limited success of immunotherapy in acute myeloid leukemia (AML), but the cellular interactions underlying AML immune evasion are incompletely understood. We therefore generated a single-cell spatial transcriptomic and proteomic atlas using 148 bone biopsies from 113 individuals comprising pediatric and adult AM...

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Literature Corpus work
246cd985-5fc7-5690-ac07-1a0c5a33bdd9
DOI
10.64898/2026.08.07.743431
Open publication

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Spatial multi-omics reveals targetable immunosuppressive macrophage T-cell interactions in human AML bone marrowDOI 10.64898/2026.08.07.743431
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