A multidimensional analysis reveals distinct immune phenotypes and the composition of immune aggregates in pediatric acute myeloid leukemia.

doi:10.1038/s41375-024-02381-w

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A multidimensional analysis reveals distinct immune phenotypes and the composition of immune aggregates in pediatric acute myeloid leukemia.

Leukemia - 1 Nov 2024

Koedijk Joost B, van der Werf Inge, Penter Livius, Vermeulen Marijn A, Barneh Farnaz, Perzolli Alicia, Meesters-Ensing Joyce I, Metselaar Dennis S, Margaritis Thanasis, Fiocco Marta, de Groot-Kruseman Hester A, Moeniralam Rubina, Bang Christensen Kristina, Porter Billie, Pfaff Kathleen, Garcia Jacqueline S, Rodig Scott J, Wu Catherine J, Hasle Henrik, Nierkens Stefan, Belderbos Mirjam E, Zwaan C Michel, Heidenreich Olaf

Abstract excerpt

Because of the low mutational burden and consequently, fewer potential neoantigens, children with acute myeloid leukemia (AML) are thought to have a T cell-depleted or 'cold' tumor microenvironment and may have a low likelihood of response to T cell-directed immunotherapies. Understanding the composition, phenotype, and spatial organization of T cells and other microenvironmental populations in the pediatric AML...

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Identifiers

PMID: 39187578
DOI: 10.1038/s41375-024-02381-w
PMCID: PMC11518988

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