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Single-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML

9 Jul 2025

Abstract excerpt

Given the graft-versus-leukemia effect observed with allogeneic hematopoietic stem cell transplantation in refractory or relapsed acute myeloid leukemia (AML), immunotherapies have been explored in nontransplant settings. We applied a multiomic approach to examine bone marrow interactions in patients with AML treated with pembrolizumab and decitabine. Using extensively trained nuclear and membrane segmentation...

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PMID: 40632867
DOI: 10.1126/sciadv.adw4871

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