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Bone marrow tumor microenvironment profiling predicts distinct immunosuppressive phenotypes and immunotherapy potential in AML patients

23 Jun 2025

Abstract excerpt

The immune landscape of acute myeloid leukemia (AML) is poorly understood, and its myeloid origins complicate the distinction between pathological and immunoregulatory components. We refined the AML microenvironment (AME) classification, demonstrating distinct immunophenotypes from AML lineages and maturation stages. We developed distinct 13-gene megakaryocytic/erythroid (MK/Ery) and 16-gene...

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PMID: 40555045
DOI: 10.1016/j.biopha.2025.118287

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