Article

Functional regulatory variants implicate distinct transcriptional networks in dementia

2021-06-15

Abstract excerpt

Predicting functionality of noncoding variation is one of the major challenges in modern genetics. We employed massively parallel reporter assays to screen 5,706 variants from genome-wide association studies for both Alzheimer’s disease (AD) and Progressive Supranuclear Palsy (PSP). We identified 320 functional regulatory polymorphisms (SigVars) comprising 27 of 34 unique tested loci, including multiple independen...

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Literature Corpus work: 2467b00e-5793-57fe-ad19-0923e9cf1b09
DOI: 10.1101/2021.06.14.448395

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