Article

Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy

2023-12-30

Abstract excerpt

<h4>Background</h4> Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. Previous genome-wide association studies for PSP were based on genotype array, therefore, were inadequate for the analysis of rare variants as well as larger mutations, such as small insertions/deletions (indels) and...

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Literature Corpus work: b835a4d5-5b43-5dca-a14c-f5e47ef308d9
DOI: 10.1101/2023.12.28.23300612

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