A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy.

doi:10.1001/jamaneurol.2014.4040

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Article

A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy.

JAMA neurology - 1 Apr 2015

Chen Jason A, Wang Qing, Davis-Turak Jeremy, Li Yun, Karydas Anna M, Hsu Sandy C, Sears Renee L, Chatzopoulou Doxa, Huang Alden Y, Wojta Kevin J, Klein Eric, Lee Jason, Beekly Duane L, Boxer Adam, Faber Kelley M, Haase Claudia M, Miller Josh, Poon Wayne W, Rosen Ami, Rosen Howard, Sapozhnikova Anna, Shapira Jill, Varpetian Arousiak, Foroud Tatiana M, Levenson Robert W, Levey Allan I, Kukull Walter A, Mendez Mario F, Ringman John, Chui Helena, Cotman Carl, DeCarli Charles, Miller Bruce L, Geschwind Daniel H, Coppola Giovanni

Abstract excerpt

IMPORTANCE: Previous studies have indicated a heritable component of the etiology of neurodegenerative diseases such as Alzheimer disease (AD), frontotemporal dementia (FTD), and progressive supranuclear palsy (PSP). However, few have examined the contribution of low-frequency coding variants on a genome-wide level. OBJECTIVE: To identify low-frequency coding variants that affect susceptibility to AD, FTD, and...

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Identifiers

PMID: 25706306
DOI: 10.1001/jamaneurol.2014.4040
PMCID: PMC4397175

Genes

ABCA7
DYSF
PAXIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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