Article

Integrated genomics and comprehensive validation reveal novel drivers of genomic evolution in esophageal adenocarcinoma

2020-04-25

Abstract excerpt

Identification of genes driving genomic evolution can provide novel targets for cancer treatment and prevention. Here we show identification of a genomic instability gene signature, using an integrated genomics approach. Elevated expression of this signature correlated with poor survival in esophageal adenocarcinoma (EAC) as well as three other human cancers. Knockout and overexpression screens confirmed the relev...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e18b04a-793c-5874-8049-6b6e254f15b7
DOI: 10.1101/2020.04.23.058230

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated genomics and comprehensive validation reveal novel drivers of genomic evolution in esophageal adenocarcinomaDOI 10.1101/2020.04.23.058230Read

Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma.Semantic proximity Read

Unearthed Novel Molecular Phenotypes and Potential Therapeutic Targets in Esophagogastric AdenocarcinomaSemantic proximity Read

Genomics and Targeted Therapies in Gastroesophageal AdenocarcinomaSemantic proximity Read

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance.Semantic proximity Read

Apurinic/apyrimidinic nuclease 1 drives genomic evolution contributing to chemoresistance and tumorigenesis in solid tumorSemantic proximity Read

Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences.Semantic proximity Read

Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy.Semantic proximity Read

Multiomics analysis of homologous recombination deficiency across cancer types.Semantic proximity Read

Genetic landscape of esophageal squamous cell carcinoma.Semantic proximity Read

Actionable Alterations for Molecular Targeted Therapy in Esophageal Cancer: An AACR Project GENIE ReviewSemantic proximity Read

Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy durationSemantic proximity Read

Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell CarcinomaSemantic proximity Read