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Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma

22 Aug 2017

Abstract excerpt

Ape1 is the major apurinic/apyrimidinic (AP) endonuclease activity in mammalian cells, and a key factor in base-excision repair of DNA. High expression or aberrant subcellular distribution of Ape1 has been detected in many cancer types, correlated with drug response, tumor prognosis, or patient survival. Here we present evidence that Ape1 facilitates BRCA1-mediated homologous recombination repair (HR), while...

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PMID: 28852018
DOI: 10.1038/s41598-017-10013-w

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