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APE1 promotes radiation resistance against radiation-induced pyroptosis by inhibiting the STING pathway in lung adenocarcinoma

2023-04-11

Abstract excerpt

Mammalian apurinic/apyrimidinic endonuclease 1 (APE1, APEX1) is a multifunctional enzyme that maintains cell homeostasis. It is involved in the base excision repair (BER) pathway and plays a key role in radiation-induced DNA damage response. Nevertheless, the relationship between APE1-driven radiation resistance and pyroptosis in lung adenocarcinoma (LUAD) cells and the underlying molecular mechanisms remain uncle...

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Literature Corpus work
181560e7-95e3-54db-b542-20df7432c74f
DOI
10.22541/au.168123246.61736590/v1
Open publication

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APE1 promotes radiation resistance against radiation-induced pyroptosis by inhibiting the STING pathway in lung adenocarcinomaDOI 10.22541/au.168123246.61736590/v1
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