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Human Apurinic/Apyrimidinic Endonuclease 1

8 Jul 2013

Abstract excerpt

SIGNIFICANCE: Human apurinic/apyrimidinic endonuclease 1 (APE1, also known as REF-1) was isolated based on its ability to cleave at AP sites in DNA or activate the DNA binding activity of certain transcription factors. We review herein topics related to this multi-functional DNA repair and stress-response protein. RECENT ADVANCES: APE1 displays homology to Escherichia coli exonuclease III and is a member of the...

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Identifiers

PMID: 23834463
DOI: 10.1089/ars.2013.5492

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