Article

Revisiting Two Decades of Research Focused on Targeting APE1 for Cancer Therapy: The Pros and Cons

2023-06-01

Abstract excerpt

APE1 is an essential endodeoxyribonuclease of the base excision repair pathway that maintains genome stability. It was identified as a pivotal factor favoring tumor progression and chemo-resistance through the control of gene expression by a redox-based mechanism. APE1 is overex-pressed and serum-secreted in different cancers, representing a prognostic and predictive factor, and a promising non-invasive biomarker....

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Literature Corpus work: f0031dfe-8934-54e2-9673-ef4d190f3e56
DOI: 10.20944/preprints202306.0041.v1

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