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Article

Progression of Seed-Induced Aβ Deposition within the Limbic Connectome.

Brain pathology (Zurich, Switzerland) - 1 Nov 2015

Ye Lan, Hamaguchi Tsuyoshi, Fritschi Sarah K, Eisele Yvonne S, Obermüller Ulrike, Jucker Mathias, Walker Lary C

Abstract excerpt

An important early event in the pathogenesis of Alzheimer's disease (AD) is the aberrant polymerization and extracellular accumulation of amyloid-β peptide (Aβ). In young transgenic mice expressing the human Aβ-precursor protein (APP), deposits of Aβ can be induced by the inoculation of minute am...

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Identifiers

PMID: 25677332
DOI: 10.1111/bpa.12252
PMCID: PMC4530099

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25677332-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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