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Alzheimer’s genetic risk effects on cerebral blood flow are spatially consistent and proximal to gene expression across the lifespan

2021-01-05

Abstract excerpt

Cerebrovascular dysregulation is a hallmark feature of Alzheimer’s disease (AD), where alterations in cerebral blood flow (CBF) are observed decades prior to symptom onset. Genome-wide association studies (GWAS) show that AD has a polygenic aetiology, providing a tool for studying AD susceptibility across the lifespan. Here, we ascertain whether AD genetic risk effects on CBF previously observed (Chandler et al.,...

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Identifiers and source

Literature Corpus work
240a0b90-b94a-5e43-ac53-a2ce051b9566
DOI
10.1101/2020.12.31.424949
Open publication

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Alzheimer’s genetic risk effects on cerebral blood flow are spatially consistent and proximal to gene expression across the lifespanDOI 10.1101/2020.12.31.424949
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