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Article

Non-APOE variants predominately expressed in smooth muscle cells contribute to the influence of Alzheimer's disease genetic risk on white matter hyperintensities.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2025

Chandler Hannah Louise, Wheeler Joshua, Escott-Price Valentina, Murphy Kevin, Lancaster Thomas Matthew

Abstract excerpt

INTRODUCTION: White matter hyperintensity volumes (WMHVs) are disproportionally prevalent in individuals with Alzheimer's disease (AD), potentially reflecting neurovascular injury. We quantify the association between AD polygenic risk score (AD-PRS) and WMHV, exploring single-nucleotide polymorphisms (SNPs) that are proximal to genes overexpressed in cerebrovascular cell species. METHODS: In a UK-Biobank...

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Identifiers

PMID: 39737667
DOI: 10.1002/alz.14455
PMCID: PMC11848156

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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