Article

Amyloid and Tau Pathology are Associated with Cerebral Blood Flow in a Mixed Sample of Nondemented Older Adults with and without Vascular Risk Factors for Alzheimer’s Disease

2022-09-27

Abstract excerpt

Alzheimer’s disease (AD) is the leading cause of dementia in individuals over 65 in the U.S. Prevalence is projected to double by 2050, but current treatments cannot stop the progression of AD. Treatments administered before severe cognitive decline may be effective; identification of biomarkers for preclinical and prodromal stages of AD is therefore imperative. Cerebral blood flow (CBF) is a potential early bioma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c0e008a3-cc60-5199-b6fe-49e205f944d3
DOI: 10.1101/2022.09.27.22280379

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Amyloid and Tau Pathology are Associated with Cerebral Blood Flow in a Mixed Sample of Nondemented Older Adults with and without Vascular Risk Factors for Alzheimer’s DiseaseDOI 10.1101/2022.09.27.22280379Read

The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer's Disease.Semantic proximity Read

Interplay Between Vascular Dysfunction and Neurodegenerative Pathology: New Insights into Molecular Mechanisms and ManagementSemantic proximity Read

Lower cerebral perfusion is associated with tau-PET in the entorhinal cortex across the Alzheimer's continuum.Semantic proximity Read

Associations between age, sex, APOE genotype, and regional vascular physiology in typically aging adults.Semantic proximity Read

Vascular burden and Alzheimer disease pathologic progression.Semantic proximity Read

Cerebrovascular regulation dynamics and Alzheimer's neuroimaging phenotypes.Semantic proximity Read

Cerebrovascular risk factors in Alzheimer's disease: brain hemodynamics and pharmacogenomic implications.Semantic proximity Read

Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers.Semantic proximity Read

Alzheimer’s genetic risk effects on cerebral blood flow are spatially consistent and proximal to gene expression across the lifespanSemantic proximity Read

Aerobic exercise improves hippocampal blood flow for hypertensive<i>APOE4</i>carriersSemantic proximity Read

Neuro-Metabolic and Vascular Dysfunction as an Early Diagnostic for Alzheimer’s Disease and Related DementiasSemantic proximity Read

Critical threshold cerebral hypoperfusion causes Alzheimer's disease?Semantic proximity Read