Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polygenic impact of common genetic risk loci for Alzheimer’s disease on cerebral blood flow in young individuals

24 Jan 2019

Abstract excerpt

Abstract Genome-wide association studies (GWAS) show that many common alleles confer risk for developing Alzheimer’s disease (AD). These risk loci may contribute to MRI alterations in young individuals, preceding the clinical manifestations of AD. Prior evidence identifies vascular dysregulation as the earliest marker of disease progression. However, it remains unclear whether cerebrovascular function (measured...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Dementia and Cognitive Impairment Research
Share to Genetic Associations and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30679549
DOI: 10.1038/s41598-018-36820-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polygenic impact of common genetic risk loci for Alzheimer’s disease on cerebral blood flow in young individualsPMID 30679549Read ↗

Alzheimer’s genetic risk effects on cerebral blood flow are spatially consistent and proximal to gene expression across the lifespanSemantic proximity Read ↗

Lipid-regulatory mechanisms drive cerebrovascular disease in asymptomatic individuals at low risk for late-life dementiaSemantic proximity Read ↗

Polygenic risk of Alzheimer disease is associated with early- and late-life processes.Semantic proximity Read ↗

Polygenic risk for Alzheimer's disease in healthy aging: age-related and APOE-driven effects on brain structures and cognition.Semantic proximity Read ↗

Non-APOE variants predominately expressed in smooth muscle cells contribute to the influence of Alzheimer's disease genetic risk on white matter hyperintensities.Semantic proximity Read ↗

Polygenic coronary artery disease association with brain atrophy in the cognitively impairedSemantic proximity Read ↗

Compositional structural brain signatures capture Alzheimer’s genetic risk on brain structure along the disease<i>continuum</i>Semantic proximity Read ↗

Multimodal Brain Imaging Reveals Structural Differences in Alzheimer's Disease Polygenic Risk Carriers: A Study in Healthy Young Adults.Semantic proximity Read ↗

Genetic Interplay Between White Matter Hyperintensities and Alzheimer’s Disease: A Brain-Body PerspectiveSemantic proximity Read ↗

Genetic overlap between vascular pathologies and Alzheimer's dementia and potential causal mechanismsSemantic proximity Read ↗

Multiple genetic imaging study of the association between cholesterol metabolism and brain functional alterations in individuals with risk factors for Alzheimer's disease.Semantic proximity Read ↗

Amyloid and Tau Pathology are Associated with Cerebral Blood Flow in a Mixed Sample of Nondemented Older Adults with and without Vascular Risk Factors for Alzheimer’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.