Lipid-regulatory mechanisms drive cerebrovascular disease in asymptomatic individuals at low risk for late-life dementia

Abstract excerpt

<h4>Background</h4> Cerebrovascular lesions, particularly white matter hyperintensities (WMH), are often found in middle-aged individuals with a low cardiovascular risk profile. Understanding modifiable mechanisms leading to cerebrovascular disease is fundamental for implementing preventive strategies. This study aimed to elucidate the biological mechanisms underlying the presence of WMH in cognitively unimpaired...

Topics

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• Atherosclerosis
• Dementia
• Genetic Predisposition to Disease
• Heart Disease Risk Factors
• Mendelian Randomization Analysis
• Risk Assessment
• Risk Factors
• White Matter

Identifiers and source

Literature Corpus work

19fa1834-7ffc-51d3-b892-6926871ff042

DOI

10.1101/2024.05.08.24307060