Cerebral perfusion alterations in healthy young adults due to two genetic risk factors of Alzheimer's disease: APOE and MAPT.

doi:10.1177/0271678X241310731

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Article

Cerebral perfusion alterations in healthy young adults due to two genetic risk factors of Alzheimer's disease: APOE and MAPT.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Jun 2025

Bennett Samuel K, Zeng Jianmin, Dounavi Maria-Eleni, Majid Arshad, Baig Sheharyar S, De Marco Matteo, Ritchie Craig, O'Brien John T, Su Li

Abstract excerpt

Functional brain changes such as altered cerebral blood flow occur long before the onset of clinical symptoms in Alzheimer's disease (AD) and other neurodegenerative disorders. While cerebral hypoperfusion occurs in established AD, middle-aged carriers of genetic risk factors for AD, including APOE ε4, display regional hyperperfusion due to hypothesised pleiotropic or compensatory effects, representing a possible...

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Topics

Humans
tau Proteins
Alzheimer Disease
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cerebrovascular Circulation

Apolipoproteins E

Risk Factors

Adult

Magnetic Resonance Imaging

Young Adult

Genotype

Brain

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 39763384
DOI: 10.1177/0271678X241310731
PMCID: PMC11705314

Genes

APOE
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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