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Article

Genome-wide analysis captures the determinants of the antibiotic cross-resistance interaction network.

Nature communications - 8 Jul 2014

Lázár Viktória, Nagy István, Spohn Réka, Csörgő Bálint, Györkei Ádám, Nyerges Ákos, Horváth Balázs, Vörös Andrea, Busa-Fekete Róbert, Hrtyan Mónika, Bogos Balázs, Méhi Orsolya, Fekete Gergely, Szappanos Balázs, Kégl Balázs, Papp Balázs, Pál Csaba

Abstract excerpt

Understanding how evolution of antimicrobial resistance increases resistance to other drugs is a challenge of profound importance. By combining experimental evolution and genome sequencing of 63 laboratory-evolved lines, we charted a map of cross-resistance interactions between antibiotics in Escherichia coli, and explored the driving evolutionary principles. Here, we show that (1) convergent molecular evolution...

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Share to Adaptation, Biological
Share to Drug Resistance, Multiple, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Evolution, Molecular

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Share to Selection, Genetic

Share to Sequence Analysis, DNA

Source

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Identifiers

PMID: 25000950
DOI: 10.1038/ncomms5352
PMCID: PMC4102323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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