Article

Chemical-genetic profiling reveals cross-resistance and collateral sensitivity between antimicrobial peptides

2019-02-08

Abstract excerpt

Antimicrobial peptides (AMPs) are key effectors of the innate immune system and promising therapeutic agents. Yet, knowledge on how to design AMPs with minimal cross-resistance to human host-defense peptides remains limited. Here, with a chemical-genetic approach, we systematically assessed the resistance determinants of Escherichia coli against 15 different AMPs. Although generalizations about AMP resistance are...

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Literature Corpus work: 246c1398-3400-51d0-bacf-fbe6f54c3a51
DOI: 10.1101/542548

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