Article

<i> Ras <sup>G12V</sup> </i> Oncogene-Induced Epithelial Senescence and Its Relay Promotes Host Metabolic Syndrome in <i>Drosophila</i>

2026-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Precancerous oncogenic activation in a target organ often induces senescence, a tumor-suppressive response known as oncogene-induced senescence (OIS). Clinical observations indicate a strong association of metabolic syndrome (MetS) with the precancerous and early-stage cancers. Notably, cells displaying OIS are characterized by a senescence-associated secretory phenotype (SASP), in which they se...

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Literature Corpus work: 23dfbed6-e896-5d17-bf94-67cedb5eec7a
DOI: 10.64898/2026.03.13.711573

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