Article

A tumour-host feed-forward loop contributes to malignant growth in chromosomal instability-induced epithelial tumours

2025-09-26

Abstract excerpt

Chromosomal instability (CIN), characterized by frequent changes in chromosome number and structure, is common in human carcinomas and often leads to aneuploidy. Drosophila has been instrumental in demonstrating that CIN can promote tumour growth and malignancy through aneuploidy-induced senescence, a state marked by cell-cycle arrest and high secretory activity. Despite extensive chromosomal heterogeneity, we sho...

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Literature Corpus work: 486d045c-38c8-5388-a71e-1bb015c19745
DOI: 10.1101/2025.09.24.678048

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