Article

Tumour-derived Ilp8 and Upd3 control intestinal progenitor cells depletion during cachexia in <i>Drosophila</i> larvae

2025-04-25

Abstract excerpt

<h4>SUMMARY</h4> In animals, tumour development triggers systemic effects, impacting the physiology of distant organs. In Drosophila larvae, wing disc neoplastic tumours result in developmental delay and organ wasting reminiscent of cachexia. This paraneoplastic syndrome affects many organs, but its effects on the intestine, a key organ in the regulation of nutrient and energy homeostasis, remain understudied. W...

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Literature Corpus work: 6038befc-cdb0-5e56-86a3-b2ef6ba6576c
DOI: 10.1101/2025.04.21.649791

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