Article
Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila.
Nature communications - 27 Oct 2014
Nakamura Mai, Ohsawa Shizue, Igaki Tatsushi
Abstract excerpt
Cell-cell interactions play important roles in epithelial tumorigenesis. Here we show in Drosophila imaginal epithelium that Ras activation and mitochondrial dysfunction, frequent alterations in cancers, cause cellular senescence and senescence-associated secretory phenotype (SASP), which leads to overgrowth of neighbouring tissue. Ras-activated cells express several hallmarks of cellular senescence such as...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.