Article

Microglia are not required for normal postnatal brain development and cognitive function in the rat

2025-12-24

Abstract excerpt

The development, maintenance and survival of microglia, the brain’s resident immune cells, requires signalling via the colony stimulating factor 1 receptor (CSF1R). In mice, the Fms intronic regulatory element (FIRE), a highly conserved super enhancer, is required for CSF1R expression in microglia and germ-line deletion of FIRE leads to microglial deficiency. We have generated Csf1r ΔFIRE/ΔFIRE ( Fireko ) rats...

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Literature Corpus work: 23c57ff2-a3b9-5c05-8a8a-a75b8e733462
DOI: 10.64898/2025.12.22.694658

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