Article

Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain

2018-09-03

Abstract excerpt

<h4>ABSTRACT</h4> Microglia are brain resident macrophages, which have specialized functions important in brain development and in disease. They colonize the brain in early embryonic stages, but few factors that drive the migration of yolk sac macrophages into the embryonic brain, or regulate their acquisition of specialized properties are currently known. Here, we present a CRISPR/Cas9-based in vivo reverse gene...

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Literature Corpus work: 615bbc17-c1c3-59f7-b748-ff05289a9104
DOI: 10.1101/406553

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