Article

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation

2020-11-29

Abstract excerpt

Homozygous mutation of the Csf1r locus ( Csf1rko ) in mice, rats and humans leads to multiple postnatal developmental abnormalities. To enable analysis of the mechanisms underlying the phenotypic impacts of Csf1r mutation, we bred a rat Csf1rko allele to the inbred dark agouti (DA) genetic background and to a Csf1r -mApple reporter transgene. The Csf1rko led to almost complete loss of embryonic macrophages a...

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Literature Corpus work: 451c537b-d6e1-5169-8f50-1b551a40242c
DOI: 10.1101/2020.11.29.402859

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