Article
Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy.
Acta neuropathologica - 1 Aug 2022
Berdowski Woutje M, van der Linde Herma C, Breur Marjolein, Oosterhof Nynke, Beerepoot Shanice, Sanderson Leslie, Wijnands Lieve I, de Jong Patrick, Tsai-Meu-Chong Elisa, de Valk Walter, de Witte Moniek, van IJcken Wilfred F J, Demmers Jeroen, van der Knaap Marjo S, Bugiani Marianna, Wolf Nicole I, van Ham Tjakko J
Abstract excerpt
Tissue-resident macrophages of the brain, including microglia, are implicated in the pathogenesis of various CNS disorders and are possible therapeutic targets by their chemical depletion or replenishment by hematopoietic stem cell therapy. Nevertheless, a comprehensive understanding of microglial function and the consequences of microglial depletion in the human brain is lacking. In human disease, heterozygous...
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