Article
Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations.
Neurobiology of disease - 1 Apr 2021
Patkar Omkar L, Caruso Melanie, Teakle Ngari, Keshvari Sahar, Bush Stephen J, Pridans Clare, Belmer Arnauld, Summers Kim M, Irvine Katharine M, Hume David A
Abstract excerpt
Mutations in the human CSF1R gene have been associated with dominant and recessive forms of neurodegenerative disease. Here we describe the impacts of Csf1r mutation in the rat on development of the brain. Diffusion imaging indicated small reductions in major fiber tracts that may be associated in part with ventricular enlargement. RNA-seq profiling revealed a set of 105 microglial markers depleted in all brain...
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