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Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo.

Cell reports - 31 Jul 2018

Oosterhof Nynke, Kuil Laura E, van der Linde Herma C, Burm Saskia M, Berdowski Woutje, van Ijcken Wilfred F J, van Swieten John C, Hol Elly M, Verheijen Mark H G, van Ham Tjakko J

Abstract excerpt

Microglia are brain-resident macrophages with trophic and phagocytic functions. Dominant loss-of-function mutations in a key microglia regulator, colony-stimulating factor 1 receptor (CSF1R), cause adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a progressive white matter disorder. Because it remains unclear precisely how CSF1R mutations affect microglia, we generated an allelic...

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Identifiers

PMID: 30067976
DOI: 10.1016/j.celrep.2018.06.113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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