Article

Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation

2024-07-31

Abstract excerpt

Adaptation to existence outside the womb is a key event in the life of a mammal. The absence of macrophages in rats with a homozygous mutation in the Csf1r gene ( Csf1rko ) severely compromises pre-weaning somatic growth and maturation of organ function. Transfer of wild-type bone marrow cells (BMT) at weaning rescues tissue macrophage populations permitting normal development and long-term survival. To dissect...

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Literature Corpus work: c40e8e2b-fce2-55bc-9613-f2dc31e00f6c
DOI: 10.1101/2024.07.30.605701

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