Article

Peripheral macrophages causally contribute to disease onset and progression in the Ndufs4 (KO) model of Leigh syndrome

2023-01-27

Abstract excerpt

Subacute necrotizing encephalopathy, or Leigh syndrome (LS), is the most common paediatric presentation of genetic mitochondrial disease. LS is a multi-system disorder with severe neurologic, metabolic, and musculoskeletal symptoms. The presence of progressive, symmetric, necrotizing lesions in the brainstem are a defining feature of the disease, and the major cause of morbidity and mortality, but the mechanisms u...

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Literature Corpus work: 6f95241c-22b0-503a-a289-ed055a3329a3
DOI: 10.1101/2023.01.27.525842

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Peripheral macrophages causally contribute to disease onset and progression in the Ndufs4 (KO) model of Leigh syndromeDOI 10.1101/2023.01.27.525842Read

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Peripheral macrophages causally contribute to disease onset and progression in the <i>Ndufs4</i> (KO) model of Leigh syndrome

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