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Article

A csf1rb mutation uncouples two waves of microglia development in zebrafish.

Development (Cambridge, England) - 11 Jan 2021

Ferrero Giuliano, Miserocchi Magali, Di Ruggiero Elodie, Wittamer Valérie

Abstract excerpt

In vertebrates, the ontogeny of microglia, the resident macrophages of the central nervous system, initiates early during development from primitive macrophages. Although murine embryonic microglia then persist through life, in zebrafish these cells are transient, as they are fully replaced by an adult population originating from larval hematopoietic stem cell (HSC)-derived progenitors. Colony-stimulating factor...

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PMID: 33298459
DOI: 10.1242/dev.194241

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